We support cutting-edge research by receiving requests for pharmacology study from over 1,000 pharmaceutical companies and bio-tech in 30 countries around the world.
Providing drug efficacy pharmacology tests using inflammation and fibrosis model mice
Well-versed with fibrosis models for each organ (liver, skin, kidney, lung, intestine)
Based in Tokyo, Having many established disease models including「fibrosis」 Non-clinical CRO with extensive experience in various disease area
Our animal facilities are approved by the National Institutes of Health (NIH). We have obtained Animal Welfare Assurance approval and Our clients can receive our contracted services using subsidies from the U.S. Public Health Service (PHS).
Our pathology specialists support the construction of experimental analysis systems, data acquisition and explanation of results, and maximize the information from the histology samples of pharmacology studies conducted by clients.
With our expertise in inflammation and fibrosis, we will perform histopathological quantification and scoring for each tissue.
Fibrosis evaluation
alpha-SMA immunostaining, ER-TR7 immunostaining, Sirius red staining, Masson trichrome staining, etc.
Inflammation evaluation
F4 / 80 immunostaining, Gr-1 immunostaining, CD4 immunostaining, etc.
Fat deposition evaluation
Oil red staining
Cell proliferation / apoptosis evaluation
Ki67 immunostaining, TUNEL staining, etc.
Human tissue evaluation
HE staining, Sirius red staining, etc.
Utilizing our expertise in fibrosis, we provide a fibrosis analysis method suitable for each disease model tissue.
Alpha-SMA immunostaining
Model: DSS model
Sirius red staining
Model: UUO model
Masson trichrome staining
Model: BLM model
Embedding of human and animal tissues in paraffin (FFPE blocks) from fixed tissues.
Histopathological parameters are important endpoints in nonclinical as well as clinical studies in NASH and liver fibrosis.
As a leading CRO in MASH/NASH, SMC has accumulated know-how by assessing over 500 pharmacology studies and 50,000 slides of MASH/NASH and related diseases in mouse, rat and human.
- judgment of NAS (especially, ballooning), assessment of pathological changes from disease control, discussion of clinical relevance… and more!
NAS; NAFLD Activity score
NAS (including ballooning, inflammation, steatosis) is an important parameter to evaluate the drug efficacy in MASH/NASH in both human and animal models.
In order to translate nonclinical results into clinical practice, it is essential to discriminate “true”- from “pseudo”-ballooning in disease models.
An accurate scoring can evaluate the efficacy of the test substances on each components (steatosis, lobular inflammation, hepatocyte ballooning) of NAS.
Centered around our proprietary STAM™ model, we offer a lineup of 25 highly-rated SMC quality models. We also provide transportation, material supply, and other services in order meet your needs.
On top of supplying pathological model mice, SMC Laboratories can also provide clients with blood, tissue, and other various biological samples. The approximate delivery date for samples from each model mouse varies.
From the preparation of our disease models, to the pharmacological analysis and pathological evaluation, we consider everything in regards to the clinical research process.
In other words, we strive to make our research easily translatable to the clinical research phase.
Model preparation: Our models have clear similarities with clinical onset mechanisms
Pathology: Our models utilize the same pathological evaluation methods as clinical trials